For an oocyte to generally be All set for fertilization and expansion into an embryo, the best list of genes must be turned on. Namekawa suspected that this pre-programming of your oocyte genome takes place in several phases — the main one particular starting off round the time a female is born. He believed that chromatin remodeling proteins did much of this get the job done, by shifting spools about.
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Utilizing the GCRLE grant, Munakata and Namekawa will glimpse much more closely at how oocytes are genomically primed and saved for later on use. They can look into the function of a chromatin remodeler in oocyte survival and fertility.
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